{"id":34218,"date":"2024-01-31T09:48:45","date_gmt":"2024-01-31T08:48:45","guid":{"rendered":"https:\/\/www.sacome.com\/usine-de-production-dinsuline\/"},"modified":"2025-02-11T12:05:15","modified_gmt":"2025-02-11T11:05:15","slug":"usine-de-production-dinsuline","status":"publish","type":"post","link":"https:\/\/www.sacome.com\/fr\/usine-de-production-dinsuline\/","title":{"rendered":"Usine de production d&rsquo;insuline glargine"},"content":{"rendered":"<p>[et_pb_section fb_built=\u00a0\u00bb1&Prime; admin_label=\u00a0\u00bbsection\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.63&Prime; background_image=\u00a0\u00bbhttps:\/\/www.sacome.com\/wp-content\/uploads\/2018\/02\/insulina.png\u00a0\u00bb parallax=\u00a0\u00bbon\u00a0\u00bb][et_pb_row custom_padding=\u00a0\u00bb30px|0px|0px|0px\u00a0\u00bb admin_label=\u00a0\u00bbrow\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.63&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_blurb admin_label=\u00a0\u00bbBlurb\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.87&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb text_orientation=\u00a0\u00bbcenter\u00a0\u00bb animation=\u00a0\u00bbbottom\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=\u00a0\u00bb0px|0px|0px|0px\u00a0\u00bb admin_label=\u00a0\u00bbrow\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.47&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_text admin_label=\u00a0\u00bbText\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.87&Prime; background_color=\u00a0\u00bbrgba(53,120,155,0.55)\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb text_orientation=\u00a0\u00bbcenter\u00a0\u00bb background_layout=\u00a0\u00bbdark\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb]Echangeurs de chaleur tubulaires pour la production d&rsquo;insuline glargine<br \/>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1&Prime; admin_label=\u00a0\u00bbsection\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.47&Prime; custom_padding=\u00a0\u00bb54px|0px|0px|0px\u00a0\u00bb][et_pb_row custom_padding=\u00a0\u00bb27px|0px|15px|0px\u00a0\u00bb admin_label=\u00a0\u00bbrow\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.47&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb2_3&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_text admin_label=\u00a0\u00bbText\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.87&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb]<\/p>\n<p><strong>\u00c9changeurs de chaleur tubulaires pour la production d&rsquo;insuline : informations g\u00e9n\u00e9rales<\/strong><br \/> L&rsquo;un des leaders mondiaux de l&rsquo;industrie pharmaceutique, dont la gamme de produits propose des m\u00e9dicaments pour diff\u00e9rents domaines th\u00e9rapeutiques tels que les troubles cardiovasculaires, thrombotiques ou m\u00e9taboliques, a confi\u00e9 \u00e0 SACOME le calcul, la conception et la fabrication des \u00e9changeurs de chaleur tubulaires pour son usine de production d&rsquo;insuline \u00e0 Francfort-sur-le-Main (Allemagne).<\/p>\n<p>La fourniture de ce projet consiste en 17 \u00e9changeurs de chaleur \u00e0 tubes corrugu\u00e9s pour le chauffage et le refroidissement de diff\u00e9rents produits tels que des suspensions de prot\u00e9ines, du n-propanol \u00e0 30% ou du n-propanol \u00e0 10%. Cette installation du secteur de la bio\u00e9nergie a une capacit\u00e9 de production de 1 700 kg d&rsquo;insuline glargine par an.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_3&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_divider show_divider=\u00a0\u00bboff\u00a0\u00bb height=\u00a0\u00bb60&Prime; disabled_on=\u00a0\u00bbon|on|off\u00a0\u00bb _builder_version=\u00a0\u00bb3.2&Prime;][\/et_pb_divider][et_pb_image src=\u00a0\u00bbhttps:\/\/www.sacome.com\/wp-content\/uploads\/2018\/02\/configuracion-hexamerica-insulina.jpg\u00a0\u00bb alt=\u00a0\u00bbUsine de production d&rsquo;insuline glargine\u00a0\u00bb title_text=\u00a0\u00bbConfiguration hexam\u00e9ricaine de l&rsquo;insuline\u00a0\u00bb align=\u00a0\u00bbcenter\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.74&Prime; animation_style=\u00a0\u00bbslide\u00a0\u00bb animation_direction=\u00a0\u00bbleft\u00a0\u00bb animation_duration=\u00a0\u00bb500ms\u00a0\u00bb animation_intensity_slide=\u00a0\u00bb10%\u00a0\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=\u00a0\u00bb8px|0px|27px|0px\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.47&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb2_3&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_text admin_label=\u00a0\u00bbText\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.87&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb]Sp\u00e9cifications des produits et processus de production de l&rsquo;insuline<br \/>\nDiff\u00e9rents produits sont trait\u00e9s dans les \u00e9changeurs de chaleur tubulaires de cette ligne de production, tels que ceux \u00e9num\u00e9r\u00e9s ci-dessous :<\/p>\n<p>Diff\u00e9rentes solutions.<br \/>\nSuspensions de prot\u00e9ines.<br \/>\n30% de N-propanol.<br \/>\nSolutions de r\u00e9g\u00e9n\u00e9ration.<br \/>\nD\u00e9riv\u00e9s de chromatographie.<br \/>\n10% N-propanol.<br \/>\nEaux us\u00e9es organiques.<br \/>\nNotre \u00e9quipe d&rsquo;ing\u00e9nieurs a pris en consid\u00e9ration cette gamme de produits et, en \u00e9troite collaboration avec le client, a fix\u00e9 les diff\u00e9rentes propri\u00e9t\u00e9s thermiques (densit\u00e9, chaleur sp\u00e9cifique, conductivit\u00e9 thermique et viscosit\u00e9) pour chaque cas, afin de r\u00e9aliser avec la plus grande pr\u00e9cision la conception thermique des diff\u00e9rentes sections, dont certaines fonctionnaient comme chauffage\/refroidissement au point d&rsquo;utilisation, et d&rsquo;autres comme recirculation ou processus par lots.<\/p>\n<p>En outre, nos techniciens ont s\u00e9lectionn\u00e9 les trac\u00e9s des tuyaux qui permettaient d&rsquo;obtenir des nombres de Reynolds et des vitesses de traitement ad\u00e9quats, contribuant ainsi \u00e0 \u00e9viter la stagnation des liquides.<br \/>\n[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_3&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_divider show_divider=\u00a0\u00bboff\u00a0\u00bb height=\u00a0\u00bb120&Prime; disabled_on=\u00a0\u00bbon|on|off\u00a0\u00bb _builder_version=\u00a0\u00bb3.2&Prime;][\/et_pb_divider][et_pb_image src=\u00a0\u00bbhttps:\/\/www.sacome.com\/wp-content\/uploads\/2017\/08\/Intercambiadores-Tubulares-para-produccion-de-agua-para-usos-farmaceuticos-1.jpg\u00a0\u00bb alt=\u00a0\u00bbEchangeurs de chaleur tubulaires pour la production d&rsquo;insuline glargine\u00a0\u00bb title_text=\u00a0\u00bbProduction d&rsquo;insuline glargine\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.74&Prime; animation_style=\u00a0\u00bbslide\u00a0\u00bb animation_direction=\u00a0\u00bbleft\u00a0\u00bb animation_duration=\u00a0\u00bb500ms\u00a0\u00bb animation_intensity_slide=\u00a0\u00bb10%\u00a0\u00bb][\/et_pb_image][et_pb_divider show_divider=\u00a0\u00bboff\u00a0\u00bb height=\u00a0\u00bb40&Prime; disabled_on=\u00a0\u00bbon|on|off\u00a0\u00bb _builder_version=\u00a0\u00bb3.2&Prime;][\/et_pb_divider][et_pb_image src=\u00a0\u00bbhttps:\/\/www.sacome.com\/wp-content\/uploads\/2018\/02\/insulina.png\u00a0\u00bb alt=\u00a0\u00bb\u00c9changeurs de chaleur tubulaires pour la production d&rsquo;insuline glargine\u00a0\u00bb title_text=\u00a0\u00bbUsine de production d&rsquo;insuline glargine\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.74&Prime; animation_style=\u00a0\u00bbslide\u00a0\u00bb animation_direction=\u00a0\u00bbleft\u00a0\u00bb animation_duration=\u00a0\u00bb500ms\u00a0\u00bb animation_intensity_slide=\u00a0\u00bb10%\u00a0\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime; custom_padding=\u00a0\u00bb12px|0px|28px|0px\u00a0\u00bb][et_pb_row custom_padding=\u00a0\u00bb16px|0px|27px|0px\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.47&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_text _builder_version=\u00a0\u00bb3.0.87&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb]<\/p>\n<p>Conception d&rsquo;\u00e9changeurs de chaleur tubulaires pour la production d&rsquo;insuline<br \/> Atteindre les plus hauts niveaux de s\u00e9curit\u00e9, d&rsquo;efficacit\u00e9 et d&rsquo;asepsie a \u00e9t\u00e9 la principale consid\u00e9ration dans la s\u00e9lection de l&rsquo;\u00e9quipement. Dans le cas des \u00e9changeurs de chaleur, la n\u00e9cessit\u00e9 de respecter les recommandations de la FDA et des BPF en termes de vitesse, d&rsquo;auto-drainabilit\u00e9, de rugosit\u00e9 interne, sans zones mortes, etc. a conduit \u00e0 exclure l&rsquo;utilisation de certains types d&rsquo;\u00e9changeurs de chaleur, qui ne constituent pas la solution la plus recommandable pour r\u00e9pondre \u00e0 certaines exigences, comme c&rsquo;est le cas pour les \u00e9changeurs de chaleur \u00e0 plaques.<\/p>\n<p>Dans cette optique, nous recommandons au client notre mod\u00e8le P-TFM-I, sp\u00e9cialement con\u00e7u pour les applications pharmaceutiques. Voici les principales caract\u00e9ristiques de la solution propos\u00e9e :<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=\u00a0\u00bb32px|0px|33px|0px\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.47&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb1_2&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_toggle title=\u00a0\u00bbConception sans zone morte\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.63&Prime;]La ligne pharmaceutique d&rsquo;\u00e9changeurs de chaleur tubulaires de SACOME est sp\u00e9cialement con\u00e7ue pour \u00e9viter les zones mortes o\u00f9 les colonies bact\u00e9riennes peuvent s&rsquo;accumuler, emp\u00eachant ainsi la croissance de ces micro-organismes. Pour cela, nous consid\u00e9rons que les brides st\u00e9riles sont les connexions les plus appropri\u00e9es pour l&rsquo;\u00e9quipement.<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/www.sacome.com\/wp-content\/uploads\/2017\/06\/Intercambiador-Tubular-Farmaceutico_P-TFM-I_SACOME.png\" alt=\"Intercambiador de calor multitubo farmac\u00e9utico de haz tubular no extraible.\" \/><br \/>\n[\/et_pb_toggle][et_pb_toggle title=\u00a0\u00bb\u00c9lectropolissage\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.63&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb]L&rsquo;une des exigences du client \u00e9tait que l&rsquo;ensemble du canal du produit (tubes int\u00e9rieurs, plaques tubulaires, r\u00e9ductions excentriques et coudes) soit \u00e9lectropoli. Cet aspect est clairement d\u00e9taill\u00e9 dans la section suivante.<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/www.sacome.com\/wp-content\/uploads\/2017\/05\/Intercambiadores-Multitubulares-Farmaceuticos-en-bastidor_SACOME-300x249.png\" alt=\"Intercambiadores de calor farmac\u00e9uticos SACOME\" \/><br \/>\n[\/et_pb_toggle][et_pb_toggle title=\u00a0\u00bbChambres \u00e0 air\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.63&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb]Pour les tubes int\u00e9rieurs, nos ing\u00e9nieurs ont s\u00e9lectionn\u00e9 des tubes DIN 1.4435 (316L) avec une rugosit\u00e9 certifi\u00e9e Ra \u2264 0.8 \u00b5m (finition polie), conforme aux recommandations de l&rsquo;ASME BPE.<br \/>\n[\/et_pb_toggle][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_2&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_toggle title=\u00a0\u00bbConception de la double plaque tubulaire\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.63&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb]L&rsquo;\u00e9quipement est fabriqu\u00e9 dans une version \u00e0 double plaque, qui permet de d\u00e9tecter les fuites, \u00e9vitant ainsi la contamination crois\u00e9e (par exemple, une fuite de liquide de service dans le canal du produit) en cas de rupture d&rsquo;une soudure. L&rsquo;industrie propose d&rsquo;autres solutions \u00e0 cette fin, telles que la configuration \u00e0 double tube avec chambre interm\u00e9diaire, bien qu&rsquo;elle ne soit pas aussi efficace sur le plan thermique en raison de la r\u00e9sistance thermique de la chambre interm\u00e9diaire.<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/www.sacome.com\/wp-content\/uploads\/2017\/05\/Galeria-intercambiador-multitubular-farmaceutico-150x150.jpg\" alt=\"Intercambiadores de calor con doble placa tubular\" \/><br \/>\n[\/et_pb_toggle][et_pb_toggle title=\u00a0\u00bbAnalyse de fatigue\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.63&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb]Notre d\u00e9partement technique a analys\u00e9 les programmes de temp\u00e9rature de production et de nettoyage, ainsi que la st\u00e9rilisation des diff\u00e9rentes positions, et a recommand\u00e9 de placer un joint de dilatation dans l&rsquo;\u00e9quipement. En tant qu&rsquo;entreprise de r\u00e9f\u00e9rence mondiale concevant et fabriquant des joints de dilatation depuis 1978, nous avons v\u00e9rifi\u00e9 le calcul de ce composant en tenant compte des dilatations thermiques, ainsi que du nombre de cycles.<br \/>\n[\/et_pb_toggle][et_pb_toggle title=\u00a0\u00bb\u00a0Joints<br \/>\n\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.63&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb]Compte tenu des conditions de conception (dans certains cas, jusqu&rsquo;\u00e0 40 bars de pression) et de la n\u00e9cessit\u00e9 de disposer de joints conformes aux normes FDA et GMP, nos ing\u00e9nieurs, en \u00e9troite collaboration avec nos fournisseurs de joints, ont d\u00e9cid\u00e9 de choisir des joints \u00e0 anneau m\u00e9tallique DIN 1.4541, avec deux couches de graphite recouvertes de PTFE (T\u00e9flon).<br \/>\n[\/et_pb_toggle][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime; custom_padding=\u00a0\u00bb20px|0px|40px|0px\u00a0\u00bb][et_pb_row _builder_version=\u00a0\u00bb3.0.47&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb1_3&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_image src=\u00a0\u00bbhttps:\/\/www.sacome.com\/wp-content\/uploads\/2017\/05\/Intercambiador-multi-tubular-farmaceutico.jpg\u00a0\u00bb alt=\u00a0\u00bbL&rsquo;\u00e9changeur de chaleur tubulaire P-TFM-I comprend une double plaque tubulaire qui \u00e9vite le risque de contamination crois\u00e9e entre le produit et le service.\u00a0\u00bb title_text=\u00a0\u00bb\u00c9changeur de chaleur tubulaire P-TFM-I avec finition \u00e9lectropolie\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.74&Prime; animation_style=\u00a0\u00bbslide\u00a0\u00bb animation_direction=\u00a0\u00bbleft\u00a0\u00bb animation_duration=\u00a0\u00bb500ms\u00a0\u00bb animation_intensity_slide=\u00a0\u00bb10%\u00a0\u00bb][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_3&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_image src=\u00a0\u00bbhttps:\/\/www.sacome.com\/wp-content\/uploads\/2018\/02\/intercambiador-farmaceutico-para-produccion-de-insulina.jpg\u00a0\u00bb alt=\u00a0\u00bbL&rsquo;\u00e9changeur de chaleur tubulaire P-TFM-I comprend une double plaque tubulaire qui \u00e9vite le risque de contamination crois\u00e9e entre le produit et le service.\u00a0\u00bb title_text=\u00a0\u00bb\u00c9changeur de chaleur tubulaire pharmaceutique P-TFM-I \u00a0\u00bb _builder_version=\u00a0\u00bb3.0.74&Prime; animation_style=\u00a0\u00bbslide\u00a0\u00bb animation_direction=\u00a0\u00bbleft\u00a0\u00bb animation_duration=\u00a0\u00bb500ms\u00a0\u00bb animation_intensity_slide=\u00a0\u00bb10%\u00a0\u00bb][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_3&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_image src=\u00a0\u00bbhttps:\/\/www.sacome.com\/wp-content\/uploads\/2018\/02\/Intercambiador-tubular-farmaceutico-SACOME.jpg\u00a0\u00bb alt=\u00a0\u00bb\u00c9changeur de chaleur multitubulaire \u00e0 faisceau tubulaire non d\u00e9montable avec plaque tubulaire double.\u00a0\u00bb title_text=\u00a0\u00bb\u00c9changeur de chaleur P-TFM-I\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.74&Prime; animation_style=\u00a0\u00bbslide\u00a0\u00bb animation_direction=\u00a0\u00bbleft\u00a0\u00bb animation_duration=\u00a0\u00bb500ms\u00a0\u00bb animation_intensity_slide=\u00a0\u00bb10%\u00a0\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime; custom_padding=\u00a0\u00bb6px|0px|40px|0px\u00a0\u00bb][et_pb_row custom_padding=\u00a0\u00bb7px|0px|0px|0px\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.47&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb1_2&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_text _builder_version=\u00a0\u00bb3.0.74&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb]\u00c9lectropolissage<br \/>\n[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_2&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_divider show_divider=\u00a0\u00bboff\u00a0\u00bb height=\u00a0\u00bb100&Prime; disabled_on=\u00a0\u00bbon|on|off\u00a0\u00bb _builder_version=\u00a0\u00bb3.2&Prime;][\/et_pb_divider][et_pb_image src=\u00a0\u00bbhttps:\/\/www.sacome.com\/wp-content\/uploads\/2018\/02\/Principio-de-electropulido.png\u00a0\u00bb alt=\u00a0\u00bbDans l&rsquo;\u00e9lectropolissage, \u00e9galement appel\u00e9 polissage \u00e9lectrolytique ou anodique, l&rsquo;\u00e9quipement est immerg\u00e9 dans un bain d&rsquo;\u00e9lectrolyte dont la temp\u00e9rature est r\u00e9gul\u00e9e.\u00a0\u00bb title_text=\u00a0\u00bbProcessus d&rsquo;\u00e9lectropolissage\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.74&Prime; animation_style=\u00a0\u00bbslide\u00a0\u00bb animation_direction=\u00a0\u00bbleft\u00a0\u00bb animation_duration=\u00a0\u00bb500ms\u00a0\u00bb animation_intensity_slide=\u00a0\u00bb10%\u00a0\u00bb][\/et_pb_image][et_pb_text _builder_version=\u00a0\u00bb3.0.74&Prime; text_font_size=\u00a0\u00bb12&Prime; text_orientation=\u00a0\u00bbcenter\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb]<\/p>\n<p style=\"text-align: center;\">1. \u00c9lectrolyte<br \/>\n2. Cathode<br \/>\n3. Pi\u00e8ce \u00e0 polir (anode)<br \/>\n4. Particule se d\u00e9pla\u00e7ant de la pi\u00e8ce vers la cathode<br \/>\n5. Surface avant polissage<br \/>\n6. Surface apr\u00e8s polissage<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime; custom_padding=\u00a0\u00bb2px|0px|16px|0px\u00a0\u00bb][et_pb_row custom_padding=\u00a0\u00bb5px|0px|23px|0px\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.47&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_text _builder_version=\u00a0\u00bb3.0.87&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb]<strong>Inspections et certifications<\/strong><br \/>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1&Prime; admin_label=\u00a0\u00bbsection\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.63&Prime; custom_padding=\u00a0\u00bb50px|0px|0px|0px\u00a0\u00bb][et_pb_row custom_padding=\u00a0\u00bb27px|0px|33px|0px\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.47&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_text _builder_version=\u00a0\u00bb3.0.87&Prime; text_text_color=\u00a0\u00bb#35789b\u00a0\u00bb text_font_size=\u00a0\u00bb32px\u00a0\u00bb text_line_height=\u00a0\u00bb2em\u00a0\u00bb background_color=\u00a0\u00bb#ffffff\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb border_width_all=\u00a0\u00bb0px\u00a0\u00bb border_color_all=\u00a0\u00bb#35789b\u00a0\u00bb border_style_all=\u00a0\u00bbsolid\u00a0\u00bb text_orientation=\u00a0\u00bbcenter\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb custom_margin=\u00a0\u00bb|||\u00a0\u00bb use_border_color=\u00a0\u00bbon\u00a0\u00bb border_color=\u00a0\u00bb#35789b\u00a0\u00bb]Le projet en chiffres<br \/>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=\u00a0\u00bb34px|0px|0px|0px\u00a0\u00bb admin_label=\u00a0\u00bbrow\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.63&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb1_2&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_text _builder_version=\u00a0\u00bb3.0.87&Prime; text_font_size=\u00a0\u00bb25px\u00a0\u00bb text_line_height=\u00a0\u00bb1.3em\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb text_orientation=\u00a0\u00bbcenter\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb]Production v\u00e9g\u00e9tale d&rsquo;insuline glargine (kg\/an)<br \/>\n[\/et_pb_text][et_pb_number_counter number=\u00a0\u00bb1.700&Prime; percent_sign=\u00a0\u00bboff\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.87&Prime; title_text_color=\u00a0\u00bb#000000&Prime; title_font_size=\u00a0\u00bb25px\u00a0\u00bb number_text_color=\u00a0\u00bb#35789b\u00a0\u00bb number_font_size=\u00a0\u00bb25px\u00a0\u00bb number_line_height=\u00a0\u00bb1px\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb custom_padding=\u00a0\u00bb5px|5px|5px|5px\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb][\/et_pb_number_counter][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_2&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_text _builder_version=\u00a0\u00bb3.0.87&Prime; text_font_size=\u00a0\u00bb25px\u00a0\u00bb text_line_height=\u00a0\u00bb1.3em\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb text_orientation=\u00a0\u00bbcenter\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb]\u00c9tendue de la fourniture (\u00e9changeurs de chaleur tubulaires)<br \/>\n[\/et_pb_text][et_pb_number_counter number=\u00a0\u00bb17 \u00a0\u00bb percent_sign=\u00a0\u00bboff\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.87&Prime; title_text_color=\u00a0\u00bb#000000&Prime; title_font_size=\u00a0\u00bb20px\u00a0\u00bb number_text_color=\u00a0\u00bb#35789b\u00a0\u00bb number_font_size=\u00a0\u00bb25px\u00a0\u00bb number_line_height=\u00a0\u00bb1px\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb custom_padding=\u00a0\u00bb5px|5px|5px|5px\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb][\/et_pb_number_counter][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=\u00a0\u00bb27px|0px|0px|0px\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.47&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb1_3&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_text _builder_version=\u00a0\u00bb3.0.74&Prime; text_font_size=\u00a0\u00bb25px\u00a0\u00bb text_line_height=\u00a0\u00bb1.3em\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb text_orientation=\u00a0\u00bbcenter\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb]Puissance de l&rsquo;\u00e9quipement<br \/>\n[\/et_pb_text][et_pb_number_counter number=\u00a0\u00bb10.000 \u2013 500.000 kcal\/h\u00a0\u00bb percent_sign=\u00a0\u00bboff\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.63&Prime; title_text_color=\u00a0\u00bb#000000&Prime; title_font_size=\u00a0\u00bb25px\u00a0\u00bb number_text_color=\u00a0\u00bb#35789b\u00a0\u00bb number_font_size=\u00a0\u00bb25px\u00a0\u00bb number_line_height=\u00a0\u00bb1px\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb custom_padding=\u00a0\u00bb5px|5px|5px|5px\u00a0\u00bb][\/et_pb_number_counter][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_3&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_text _builder_version=\u00a0\u00bb3.0.74&Prime; text_font_size=\u00a0\u00bb25px\u00a0\u00bb text_line_height=\u00a0\u00bb1.3em\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb text_orientation=\u00a0\u00bbcenter\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb]Gamme de d\u00e9bits<br \/>\n[\/et_pb_text][et_pb_number_counter number=\u00a0\u00bb1.000 \u2013 6.000 l\/h\u00a0\u00bb percent_sign=\u00a0\u00bboff\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.87&Prime; title_text_color=\u00a0\u00bb#000000&Prime; title_font_size=\u00a0\u00bb25px\u00a0\u00bb number_text_color=\u00a0\u00bb#35789b\u00a0\u00bb number_font_size=\u00a0\u00bb25px\u00a0\u00bb number_line_height=\u00a0\u00bb1px\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb custom_padding=\u00a0\u00bb5px|5px|5px|5px\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb][\/et_pb_number_counter][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_3&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_text _builder_version=\u00a0\u00bb3.0.74&Prime; text_font_size=\u00a0\u00bb25px\u00a0\u00bb text_line_height=\u00a0\u00bb1.3em\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb text_orientation=\u00a0\u00bbcenter\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb]Nombre de sections<br \/>\n[\/et_pb_text][et_pb_number_counter number=\u00a0\u00bb7 \u00a0\u00bb percent_sign=\u00a0\u00bboff\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.63&Prime; title_text_color=\u00a0\u00bb#000000&Prime; title_font_size=\u00a0\u00bb25px\u00a0\u00bb number_text_color=\u00a0\u00bb#35789b\u00a0\u00bb number_font_size=\u00a0\u00bb25px\u00a0\u00bb number_line_height=\u00a0\u00bb1px\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb custom_padding=\u00a0\u00bb5px|5px|5px|5px\u00a0\u00bb][\/et_pb_number_counter][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime; custom_padding=\u00a0\u00bb0px|0px|17px|0px\u00a0\u00bb][et_pb_row custom_padding=\u00a0\u00bb0px|0px|7px|0px\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.47&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_divider color=\u00a0\u00bb#e9e9e9&Prime; divider_weight=\u00a0\u00bb1px\u00a0\u00bb height=\u00a0\u00bb5&Prime; disabled_on=\u00a0\u00bbon|on|off\u00a0\u00bb _builder_version=\u00a0\u00bb3.2&Prime;][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1&Prime; admin_label=\u00a0\u00bbsection\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.74&Prime; background_color=\u00a0\u00bb#ffffff\u00a0\u00bb custom_padding=\u00a0\u00bb0px|0px|0px|0px\u00a0\u00bb][et_pb_row custom_padding=\u00a0\u00bb0px|0px|0px|0px\u00a0\u00bb parallax_method_1=\u00a0\u00bboff\u00a0\u00bb admin_label=\u00a0\u00bbrow\u00a0\u00bb _builder_version=\u00a0\u00bb3.0.47&Prime; background_color=\u00a0\u00bb#e9e9e9&Prime; background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime; _builder_version=\u00a0\u00bb3.0.47&Prime;][et_pb_cta title=\u00a0\u00bbAvez-vous besoin d&rsquo;\u00e9changeurs de chaleur pour des applications pharmaceutiques ?\u00a0\u00bb button_url=\u00a0\u00bbhttps:\/\/www.sacome.com\/fr\/contact\/\u00a0\u00bb button_text=\u00a0\u00bbContactez-nous \u00e0 l&rsquo;adresse suivante\u00a0\u00bb admin_label=\u00a0\u00bbCall To Action\u00a0\u00bb _builder_version=\u00a0\u00bb3.16&Prime; background_color=\u00a0\u00bb#ffffff\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb background_layout=\u00a0\u00bblight\u00a0\u00bb button_text_size__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_one_text_size__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_two_text_size__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_text_color__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_one_text_color__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_two_text_color__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_border_width__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_one_border_width__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_two_border_width__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_border_color__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_one_border_color__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_two_border_color__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_border_radius__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_one_border_radius__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_two_border_radius__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_letter_spacing__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_one_letter_spacing__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_two_letter_spacing__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_bg_color__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_one_bg_color__hover_enabled=\u00a0\u00bboff\u00a0\u00bb button_two_bg_color__hover_enabled=\u00a0\u00bboff\u00a0\u00bb]Notre d\u00e9partement technique vous apportera le soutien n\u00e9cessaire<br \/>\n[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>L&rsquo;un des leaders mondiaux de l&rsquo;industrie pharmaceutique a confi\u00e9 \u00e0 SACOME le calcul, la conception et la fabrication des \u00e9changeurs tubulaires de son usine d&rsquo;insuline de Francfort-sur-le-Main (Allemagne). <\/p>\n","protected":false},"author":2,"featured_media":33587,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-34218","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"_links":{"self":[{"href":"https:\/\/www.sacome.com\/fr\/wp-json\/wp\/v2\/posts\/34218"}],"collection":[{"href":"https:\/\/www.sacome.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sacome.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sacome.com\/fr\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sacome.com\/fr\/wp-json\/wp\/v2\/comments?post=34218"}],"version-history":[{"count":6,"href":"https:\/\/www.sacome.com\/fr\/wp-json\/wp\/v2\/posts\/34218\/revisions"}],"predecessor-version":[{"id":35392,"href":"https:\/\/www.sacome.com\/fr\/wp-json\/wp\/v2\/posts\/34218\/revisions\/35392"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sacome.com\/fr\/wp-json\/wp\/v2\/media\/33587"}],"wp:attachment":[{"href":"https:\/\/www.sacome.com\/fr\/wp-json\/wp\/v2\/media?parent=34218"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sacome.com\/fr\/wp-json\/wp\/v2\/categories?post=34218"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sacome.com\/fr\/wp-json\/wp\/v2\/tags?post=34218"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}